Bone & Tissue Engineering

NYSCF uses recent advances in stem cell research and tissue engineering to generate patient-specific bone. Ultimately, this engineered bone will be able to fully treat all types of bone disease and injury with custom tailored grafts and without immune rejection.


NYSCF's Latest Research on Bone & Tissue Engineering


June 11th, 2014

NYSCF Bone Engineer featured in Nature Profile

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Nature recently featured a profile on the education, background, and dynamic cross-discipline work of NYSCF Scientist Dr. Giuseppe Maria de Peppo. Dr. de Peppo focuses his research on engineering bone from stem cells using his background in technology and induced pluripotent stem cell research. His work developing the first ever vascularized bone tissue from stem cells was published last year in the Proceedings of the National Academy of Sciences of the USA and highlighted in the Wall Street Journal and other news outlets globally.

 

May 12th, 2014

Scientists investigate bone marrow development

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NYSCF - Druckenmiller Fellow Dr. Sandra Pinho of Albert Einstein College of Medicine published her latest research on bone marrow development. The research, published in Developmental Cell, helps demystify bone marrow development by tracking a specific gene expression, Osterix, through three waves of progney cells.

Bone marrow development is not well understood, therefore this research helps identify how developing bone marrow is organized with implications for tissue regeneration after injury and blood and bone diseases.

 

September 4th, 2013

NYSCF scientists publish review on Stem Cell use in Tissue Engineering

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NYSCF researchers Dr. Giuseppe Maria de Peppo and Dr. Darja Marolt published a review article in Stem Cell Research & Therapy on how modifying the human iPS cell culture environment has the potential for improving construction of various stem cell-derived tissue substitutes. Dr. de Peppo, a NYSCF Research Fellow, focuses mainly on use of human iPS cells to engineer vascularized bone to study its potential use in treatment and new bone-regeneration therapies.

 

June 6th, 2013

NYSCF Research Fellow publishes review article on Bone Engineering

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In the June 2013 issue of Current Molecular Medicine, Giuseppe Maria de Peppo, PhD, a NYSCF Research Fellow, co-wrote a review article, assessing the utility of different human progenitor cells, including stem cells, to engineer bone tissue. Currently, bone injuries and conegnital defects are treated with cadaverous bone or artificial substitutes, neither of which fully integrate with surrounding tissue or functionally repair. As an alternative, stem cells carry the potential to become customizable bone tissue. Examining embryonic stem cells, bone marrow cells, and induced pluripotent stem (iPS) cells, the authors conclude that iPS cells, derived from a patient's own skin samples, present the greatest potential to create fully functional, immune-matched bone substitutes.

 

May 6th, 2013

NYSCF scientists create human bone from skin cells

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In a step towards personalized bone grafts to treat traumatic injury or congenital defects, a study, led by Darja Marolt, PhD, and Giuseppe Maria de Peppo, PhD, and published in the Proceedings of the National Academy of Sciences, reports the generation of patient-specific bone substitutes from skin cells for repair of large bone defects. This advance will facilitate the development of customizable, three-dimensional bone grafts on-demand, matched to fit the exact needs and immune profile of a patient. Taking skin cells, the NYSCF scientists utilized an advanced technique called “reprogramming” to revert adult cells into an embryonic-like state. The researchers differentiated the resultant induced pluripotent stem (iPS) cells into bone-forming progenitors and then seeded these cells onto a three-dimensional scaffold, which was placed into an artificial, biologically active environment, a bioreactor. Analysis revealed that, even in vitro, bone formed; and, when implanted in mice, the bone matured into typical dense, mineral-rich tissue. Next steps for this proof-of-concept research include protocol optimization and long-term safety trials in animal models.

 

About Bone Disease and Injury

The sources and causes of bone defects are many and varied. From genetic malformation to traumatic injuries that can result from car accidents, domestic violence, and service in combat, the burden of bone deficiencies is massive and rapidly increasing.

While severity varies, bone defects and injuries are currently treated with bone grafts, taken either from another part of the patient’s body or a donor bone bank, or with synthetic substitutes. None of these approaches permit complex reconstruction, and they may elicit immune rejection or fail to integrate with surrounding connective tissues. For trauma patients suffering from shrapnel wounds or vehicular injury, these traditional treatments provide limited functional and cosmetic improvement.

Learn more about stem cells:

Stem Cells 101 | Videos | Stem Cell News

 

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