NYSCF – Druckenmiller Fellow Alumnus Dr. Bi-Sen Ding, of Weill Cornell Medical College, published in Nature Cell Biology on his latest work studying lung tissue regeneration. The researchers discovered that platelets trigger lung cell regeneration through a chemical signaling cascade. Further, they confirmed their results by showing diminished cell regeneration with a lack of platelets or the initial chemical signal from the platelets.
This research demonstrates an initial step towards full lung regeneration capabilities and, more immediately, provides a biological target niche for lung regenerative therapies and enhancement.
NYSCF - Robertson Stem Cell Investigator Dr. Ravindra Majeti, of Stanford University, published in Nature Medicine on his latest work studying genetic susceptibilities in acute myeloid leukemia. The researchers found that treatment success may be increased by identifying patients with a specific protein mutation and providing them with a gene-inhibiting drug.
This type of research is exrtremely important in understanding why some cancer patients respond to treatment and others do not. In addition, it is the first step towards successful personalized medicine approaches to cancer and other diseases.
NYSCF – Robertson Stem Cell Investigator Dr. Paul Tesar, of Case Western Reserve University School of Medicine, is the recipient of the International Society for Stem Cell Research (ISSCR) Outstanding Young Investigator Award for 2015. Dr. Tesar has played an integral role in shaping the stem cell field, highlighted by his 2007 Nature paper on epiblast stem cells, which led to a paradigm shift in the understanding of the regulation of stem cell pluripotency.
Recognizing the exceptional achievements by an ISSCR member and investigator in the early part of their independent career in stem cell research, the ISSCR Outstanding Young Investigator Award consists of a personal award and an invitation to present at ISSCR’s annual meeting.
NYSCF - Robertson Stem Cell Investigator Dr. Shuibing Chen, of Weill Cornell Medical College, and her team studied the development of human pancreatic cells using stem cells. Although endothelial cells, a cell type during early development, have been shown to affect mouse pancreatic development, their function in human development remains unclear.
Dr. Chen and her team published in Stem Cell Reports describing their work identifying a molecular signal that mediates cross talk between different types of cells and creating a paradigm to study different stages of organ development using human stem cells.
NYSCF - Robertson Stem Cell Investigator Dr. Jacob Hanna, of the Weitzmann Institute of Science in Israel, and his team discovered a critical role played by the modification of a signal molecule in vivo in naive and primed stem cells. In addition, the scientists identified regulatory modules that influence both naive and primed stem cell pluripotentcy in an opposing manner.
This study, published in Science, will help researchers understand why and how stem cells transition through states of differentiation through their different molecular properties. This type of research will lead to a better understanding of stem cell pluripotency and, ultimately, clinical use.
NYSCF - Robertson Neuroscience Investigator Dr. Winrich Freiwald, The Rockefeller University, published his latest work on macaque facila processing in Current Biology. The researchers identified a new 'face patch' in the brain of macaque monkeys for natural facial motion, as contrasted with a different 'facial patch' that encodes for face shape.
This finding shows that moving faces recruit different areas of the brain to process as compared to non-moving faces and suggests a new anatomical organization principle in the macaque facial-processing system. Macaque research may give clues to human brain function, particularly in high-level processes such as facial recognition and processing.
NYSCF - Robertson Neuroscience Investigator Dr. Ed Boyden, MIT Media Lab, described in Science the newest technology developed in his lab for imaging biological samples. The technology, called expansion microscopy, physically magnifies the sample itself using a swellable polymer and adding water, making the sample itself grow, as opposed to traditional microscopy using only lenses to observe samples.
This technique gives scientists the ability to image large, intact, 3D structures with nanoscale precision. This may be a key tool to use in comprehensive, precise brain mapping which would allow scientists to better understand both normal and diseased brain function.
NYSCF - Robertson Stem Cell Investigator Dr. Alex Meissner, Harvard University, published the lastest research out of his lab investigating the regulation of neural cell differentiation through epigenetic footprinting. The research, published in Nature, describes a system the scientists developed to identify the regulation of different stages of neural stem cell differentiation in a dish, which models what happens during brain development in the body.
This research creates a framwork for scientists to dissect all types of regulatory circuits for cell differentiation, which could lead to important discoveries about the development of all cell types in the body.