NYSCF's latest paper could have important implications for human reproductive technologies. The scientists showed proof of principle that genome transfer can rescue developmentally incompetent eggs, making them viable for use in reproduction. NYSCF Research Institute scientist Dr. Mitsutoshi Yamada and NYSCF – Robertson Investigator Dr. Dieter Egli used a mouse model to investigate the causes of the decline in developmental potential in aged oocytes.
Through a battery of complementary experiments transferring the genomes of differently aged mouse oocytes post ovulation, the scientists showed that the developmental decline in oocytes is primarily due to abnormal function of cytoplasmic factors, not to deterioration of the genome. This research was published in Stem Cell Reports.
NYSCF – Robertson Stem Cell Investigator Dr. Jayaraj Rajagopal, Massachusetts General Hospital and Harvard Medical School, was named as the 2017 ISSCR Dr. Susan Lim Outstanding Young Investigator Award recipient for his work studying lung stem cells and lung tissue. Dr. Rajagopal's research has provided new insights into cystic fibrosis, asthma, chronic obstructive pulmonary disorder (COPD), and lung cancers. The Award recognizes exceptional achievements by an ISSCR member and investigator in the early part of their independent career in stem cell research.
In four of the past five years, NYSCF – Robertson Stem Cell Investigators have been recognized with this prestigious award.
Previous NYSCF recipients of the Dr. Susan Lim Outstanding Young Investigator Award:
- 2015 Dr. Paul Tesar, Case Western Reserve University School of Medicine
- 2014 Dr. Valentina Greco, Yale University
- 2013 Dr. Marius Wernig, Stanford University
The 2017 ISSCR Award Recipients will be acknowledged and recognized at the ISSCR 2017 Annual Meeting on June 14-17 in Boston, Massachusetts.
NYSCF Chief of Staff David McKeon appeared on the Dr. Oz Show investigation “Exposing Experimental Stem Cell Treatments.” The segment highlighted the dangers of unproven stem cell therapies and questioned the medical practitioners and clinics involved in taking advantage of patients with nowhere else to turn. The investigation went undercover, exposing the exhorbitant charges and outlandish claims made by these unscrupulous practitioners. Dr. Sally Temple, a research scientist and President of the International Society for Stem Cell Research (ISSCR), and Montel Williams, a talk show host and multiple sclerosis patient also participated in the segment.
NYSCF – Robertson Stem Cell Investigator Dr. Kristen Brennand at the Icahn School of Medicine at Mount Sinai published her latest research using induced pluripotent stem (iPS) cells to study psychosis in Stem Cell Reports. When deriving iPS cells from two patients, each with a psychotic disorder, the scientific team serendipitously generated a non-disease-carrier control iPS cell line. This finding highlights a problem scientists face when using iPS cells for disease modeling, particularly in patients with complex genomic rearrangements.
While iPS cell lines are emerging as a go-to technology to model human disease, this paper provides evidence that scientists should use caution while doing so. Ideally, scientists would confirm that the mutations they are studying are present at every step in the process of creating iPS cell lines; however, this is difficult and sometimes impossible using current techniques. This finding sheds light on an important area of inquiry in stem cell research, and provides an impetus to identify new methos of deriving iPS cell lines with specific genetic mutations.