NYSCF - Robertson Stem Cell Investigator Dr. Feng Zhang, Broad Institute of MIT and Harvard, used a gene editing technology called CRISPR/Cas-9 mediated loss-of-function screen to conduct a full-body, genome-wide analysis of tumor growth and metastasis in mice.
Published in Cell, this screening technique sets the stage for potential future use in identifying genetic evolution of different types of cancer in vivo.
Dr. Scott Noggle, NYSCF Vice President for Stem Cell Research, presented NYSCF’s latest Alzheimer’s disease research as the keynote speaker at the Alzheimer’s Disease Resource Center’s 11th Annual Alzheimer's Disease Education Conference and Expo in Melville, New York.
This conference and physician's dinner brings together clinicians, patients, and caregivers to learn about best practices and the latest in Alzheimer’s disease research.
Women are still underrepresented in all STEM fields, a statistic NYSCF is working to change with its Initiative on Women in Science and Engineering (IWISE). In conjunction with a Cell Stem Cell paper published earlier this month by the IWISE working group, NYSCF CEO and Co-founder Susan L. Solomon participated in a podcast discussing the paper, the seven actionable strategies identified by the IWISE working group, and the future of women in science, technology, engineering, and medicine.
NYSCF - Robertson Stem Cell Investigator Dr. Ravindra Majeti, Stanford University School of Medicine, and a team of researchers showed that cancerous, immature white blood cells from patients with precursor B acute lymphoblastic leukemia can be reprogrammed into harmless macrophage cells.
The researchers showed that these reprogrammed cells were no longer able to cause disease in immunodeficient mice and that this reprogramming may already occur to some degree in patients with this type of leukemia. This research, published in the Proceedings of the National Academy of Sciences, indicates that reprogramming leukemia cells into macrophages may represent a previously unidentified therapeutic strategy for this disease.
An article describing NYSCF’s Parkinson’s disease research featuring Jack and Jeff Gernsheimer, a set of identical twins, only one of whom has Parkinson's disease, was published in Nautilus Magazine. Published as the cover story of Cell Reports in November 2014, the paper describes the work of NYSCF scientists to turn skin samples from the twins into induced pluripotent stem cells, then into the neurons affected by Parkinson’s disease.
By comparing these cells, NYSCF scientists were able to observe key features of the disease and identify targets for new potential therapeutic approaches. This research may accelerate and provide insight into new treatments and cures for all Parkinson's disease patients.
NYSCF - Robertson Neuroscience Investigator Dr. Zachary Knight and his team from the Universtiy of California, San Francisco conducted experiments that overthrow the scientific consensus on how the brain's 'hunger circuit' regulates eating. The research, published in Cell, shows that the hunger circuit in the brain responds within seconds to the presence of food, as opposed to gradually, and that neurons motivate animals to seek and obtain food, rather than directly prompting them to consume it.
These findings could reshape basic research on feeding behavior as well as direct new strategies for the development of new anti-obesity drugs.
NYSCF Robertson - Neuroscience Investigator Dr. Melissa Warden, Cornell University, and NYSCF - Robertson Stem Cell Investigator Dr. Jennifer Phillips-Cremins, Universtiy of Pennsylvania, were named 2015 Sloan Research Fellows.
This prestigious award, given annually since 1955 by the Alfred P. Sloan Foundation, recognizes outstanding young scientists, economists, and mathematicians in the United States and Canada. A total of 126 award recipients from 57 universities were named as the 2015 class.
NYSCF - Robertson Stem Cell Investigator Dr. Alex Meissner, Harvard University, published his latest work on the role of transcription factors in stem cell differentiation in Nature. The scientists analyzed genome-wide data on the effects of 38 transcription factors during differentiation of human embryonic stem cells into the three germ layers, and showed downstream effects and context-dependent changes caused by these transcription factors during the differentiation process.
Understanding step by step stem cell development is crucial for future cell replacement treatments and technologies, as well as for basic research.