NYSCF CEO Susan L. Solomon responded to "The Trials of Stem Cell Therapy," published in The New York Times on September 15, 2014 with a Letter to the Editor, refuting the article's claim that stem cell research has not delivered on its early promises of creating personalized medicine. In her letter, Ms. Solomon cited just a few of the many medical breakthroughs discovered using stem cell research in the past few years, including NYSCF's development of a cure for mitochondrial diseases, which The New York Times Magazine featured in its cover story on June 29, 2014.
NYSCF – Druckenmiller Postdoctoral Fellow Dr. Raffaella Di Micco of New York University School of Medicine was first author for a paper published in Cell Reports identifying a key protein, implicated in many different cancers, that appears to play a pivotal role in keeping stem cells in an immature or pluripotent state, meaning the cells can become any type of cell in the body. This finding has key implications on cancer research and treatments and there are ongoing clinical trials targeting this protein.
NYSCF – Robertson Stem Cell Investigator Dr. Kristen Brennand of the Icahn School of Medicine at Mount Sinai led a team of scientists that discovered that neural cell models of schizophrenia, made using induced pluripotent cells derived from patients with schizophrenia, secrete increased amounts of three types of neurotransmitters commonly associated with many psychiatric disorders.
This research, published in Stem Cell Reports, could shed light into the chemical basis for this chronic and debilitating brain disorder.
The NYSCF Conference is unique: it focuses on translational stem cell research, demonstrating the potential to advance cures for the major diseases of our time.
It is designed for those with an interest in translational medicine, including researchers, clinicians, patient advocates, government and health officials, graduate students, and industry. The panels on Wednesday are designed to reach a broader audience, including the lay public.
Neurology Today featured NYSCF – Helmsley Investigator Dr. Valentina Fossati’s latest research on multiple sclerosis in a larger story about Dr. Fossati and her personal commitment to see new treatments and cures to the clinic.
The research, published in Stem Cell Reports, describes the development of an accelerated protocol to derive oligodendrocytes, the myelin-forming cells lost in multiple sclerosis, from induced pluripotent stem cells made from skin samples of patients with primary progressive multiple sclerosis. This accelerated protocol vastly reduces the time needed to make these critical cells, enabling an accelerated path to new research goals and ultimately, treatments, and cures.
NYSCF - Robertson Stem Cell Investigator Dr. Gabsang Lee, of John's Hopkins University School of Medicine, was senior author on a Cell Stem Cell paper describing the successful reprograming of patients' skin cells into neural crest cells then adult cell types that display many biological features of familial dysautonomia, a rare genetic disorder.
Critically, the scientists developed a protocol that skips the induced pluripotent stem cell step, reducing the time needed to make neural crest cells that are more similar to familial dysautonomia patients' own cells by seven to nine months.
While less than 500 patients worldwide suffer from familial dysautonomia, dysfunctional neural crest cells cause a multitude of diseases including familial dysautonomia, facial malformations and an inability to feel pain among others. This research has the potential to transform and accelerate research on all neural crest disorders.
In conjunction with the Alzheimer’s Disease Resource Center (ADRC), NYSCF presented their latest Alzheimer’s research at the Jewish Center of the Hamptons in East Hampton. Presentations by NYSCF CEO Susan L. Solomon, NYSCF Vice President for Stem Cell Research Dr. Scott Noggle, and President of ADRC Mary-Ann Ragona explored all aspects of Alzheimer’s disease, treatment, and research.
In addition, NYSCF Leadership Council member Carol Roaman graciously hosted NYSCF scientists and guests at a cocktail reception at her house in East Hampton. Guests mingled and spoke with NYSCF scientists, learning about the latest advances in stem cell research for many disease areas such as multiple sclerosis, bone engineering, and Parkinson’s disease among many others.
NSYCF – Druckenmiller Fellow Alumnus Dr. Marco Seandal of Weill Cornell Medical College published his latest research on how paternal age effects genetic mutations in Stem Cell Reports.
The scientists' experiments showed enhanced fitness of sperm stem cells with a specific age-related mutation. In addition, the scientists model will be useful for testing many different age-related genetic mutations carried by sperm to reveal mechanisms of disease.